Last data update: May 13, 2024. (Total: 46773 publications since 2009)
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Query Trace: McElroy-Horne K[original query] |
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Reemergence and decline of dengue virus serotype 3 in Puerto Rico.
Santiago GA , McElroy-Horne K , Lennon NJ , Santiago LM , Birren BW , Henn MR , Munoz-Jordan JL . J Infect Dis 2012 206 (6) 893-901 BACKGROUND: The DENV-3 Indian subcontinent strain emerged in Puerto Rico in 1998 after a 21-year absence of this serotype. The rapid expansion of DENV-3 on the island correlated with the withdrawal of the other serotypes for 7 years. DENV-3 prevalence declined in 2008 and remains undetected. METHODS: We sequenced complete genomes of 92 DENV-3 clinical isolates to characterize the molecular evolution and phylogeography throughout 10 years of continued sampling (1998-2007). RESULTS: We document eight distinct lineages that emerged simultaneously and evolved independently. Two of the eight lineages were highly associated to transient introductions of foreign viruses, and two of the three endemic lineages covered the entire study period. We found evidence of temporal-geographical clustering only within the three endemic lineages. The phylogeography analysis combined with serotype-specific incidence data showed that transmission of a DENV serotype in a given location and time is usually correlated with the absence of the other serotype. CONCLUSIONS: Our study shows the co-transmission of DENV lineages through a complex dissemination pattern dissimilar to the evolutionary dynamics of the other serotypes in the island. High virus genetic diversity and a large naive population were underlying factors in the expansion of collapse of DENV-3 in Puerto Rico. |
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